An Inquiry into the Causes of COVID-19 Precaution Dose Vaccine Fatigue among the Adult Population in Assam (India)

When COVID-19 vaccines got authorization for emergency administration in order to attain immunity of the population against the pandemic in India, the Government rushed the people to get vaccinated. But two years into being vaccinated with the primary doses, the efficacy of the doses decreased and infection with COVID increased. The Government of India introduced the precaution dose on 10th January, 2022, but not much vaccination turn out is observed in case of precaution dose. India is facing what is known as vaccination fatigue which is causing vaccination hesitancy. This study identified the causes of vaccination fatigue among the adult population in the state of Assam, the primary cause being pandemic fatigue. With the increase in COVID cases worldwide, The Government should implement necessary steps to conquer the vaccination fatigue and decrease the vaccination hesitancy in the state. Copyright © 2022 Wolters Kluwer Medknow Publications. All rights reserved.

Molecular mechanisms responsible for SARS-CoV-2 antibody waning and vaccine escape in Omicron sublineages BA.4 and BA.5.

Mutations in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome continue to threaten the global landscape of the coronavirus disease 2019 (COVID-19) pandemic. The Omicron variant (B.1.1.529) rapidly displaced previous 'variants of concern' (VoC) in 2021 due to its high rate of transmissibility and multitude of mutations. This global influx of infections saturated healthcare systems, overwhelmed testing capacity and case reporting, and increased the COVID-19 death toll. Global health leaders are now being faced with the most transmissible COVID-19 variants yet, the Omicron sublineages BA.4 and BA.5, which contain additional spike protein (S) mutations from previous Omicron and VoC serotypes. With universally observed antibody waning, increasing vaccine-variant mismatch, and resuming international travel, the stage is set for unprecedented levels of breakthrough infections and superspreading events. In this paper, we raise awareness to these novel variants and provide context for the high likelihood of an upcoming wave of infection capable of inflicting significant disease burden on a global scale.